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The individual evidence for each compound is substantial and replicated in animal research, but the rationale for pairing them is mechanistic: it is based on what each does on its own, not on a study of the combination

Acknowledgments Thanks to our colleagues of the R

Frequency of administration In the case wherein the patient's condition does not improve, upon the doctor's discretion the administration of the compounds is administered chronically, that is, for an extended period of time, including throughout the duration of the patient's life in order to ameliorate or otherwise control or limit the symptoms of the patient's disease or condition